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Patient characteristics and pharmacokinetic data for colistin in plasma samples from patients undergoing CVVH

Journal: Antimicrobial Agents and Chemotherapy

Article Title: Colistin Pharmacokinetics in Burn Patients during Continuous Venovenous Hemofiltration

doi: 10.1128/AAC.03783-14

Figure Lengend Snippet: Patient characteristics and pharmacokinetic data for colistin in plasma samples from patients undergoing CVVH

Article Snippet: TABLE 1 Characteristic a Patient 1 Patient 2 Before CVVH During CVVH Age (yr)/gender 68/male 37/male % TBSA burn 11 51 CVVH delivered dose (mean ± SD) (ml/kg/h) 38.1 ± 11.0 28.0 ± 3.7 Weight (kg) 136.4 86.6 102.3 Urine output (ml/kg/h) 0.2 1.6 0.9 Machine and filter Prismaflex, HF1400 NxStage, CAR500 Prefilter fluid replacement (liters/h) 2 3 CMS dose (mg/kg) 2.2 1.5 2.2 Colistin C max (μg/ml) 13.6 (2.2 free) 3.4 (0.4 free) 6.7 (0.6 free) C ss.avg (mg/ml) 9.3 4.2 2.3 AUC 24 (μg · h/ml) 222.2 (18.2 free) 55.0 (6.0 free) 100.0 (8.7 free) b V (liters) 86.1 99.7 t 1/2 (h) 22 11.9 Total clearance (liters/h) 2.7 4.7 CVVH clearance (liters/h) 1.4 0.04 % CVVH clearance 51.6 Sieving coefficient 0.49 0.17 b % Free colistin (mean ± SD) 11.9 ± 9.2 13.7 ± 6.4 10.9 ± 4.6 % Colistin A (mean ± SD) 64.8 ± 1.4 67.7 ± 0.4 68.6 ± 2.1 % Colistin B (mean ± SD) 14.1 ± 1.7 10.9 ± 4.6 10.0 ± 2.4 MIC at which AUC 24 /MIC was ≥60 (μg/ml) 2 0.75 1 Open in a separate window a C max , maximum concentration; t 1/2 , half-life. b Only 0- to 8-h data available due to filter clotting.

Techniques: Clinical Proteomics